Off-label use: While enclomiphene is not FDA-approved, it has been studied for treatment of male hypogonadism and infertility. Be aware of regulatory status and source.
Monitoring: Regularly monitor testosterone and estradiol levels, semen parameters, and ensure no contraindications (like liver disease or tumors).
Indications/Use
Investigational use for secondary hypogonadism (hypogonadotropic hypogonadism) in men desiring fertility.
Acts as an estrogen receptor antagonist in the hypothalamus, leading to increased GnRH, LH, and FSH secretion → endogenous testosterone production and spermatogenesis.
Contraindications
Known hypersensitivity to enclomiphene or related compounds (e.g., clomiphene).
Liver disease or hepatic dysfunction.
Pituitary or hypothalamic tumors (as enclomiphene stimulates these pathways).
Caution in those with elevated prolactin levels. Usually recommend MRI to clear prior to starting.
Side Effects
Common: Hot flashes/night sweats (can occur with aromatization), mood swings, headache, visual disturbances (like blurred vision).
Gastrointestinal: Nausea, abdominal discomfort.
Reproductive: Testicular discomfort (due to increased activity), erection changes, potential for multiple pregnancies in women if used off-label (not relevant in men).
Thromboembolic risk: Rare but possible due to estrogen receptor modulation.
Long-term use: Limited data—caution with chronic use.